K-Ras-IN-3
K-Ras-IN-3 (compound 3) is a potent and selective inhibitor of the GDP-bound KRAS G12V mutant, demonstrating an IC50 of 0.371 nM. This small molecule is a valuable chemical probe for investigating KRAS-driven oncogenesis in both cellular and animal models of cancer.
Product Specifications
CAS Number
3024991-82-7
Field of Research
Signal Transduction
Smiles
C (C (O) =O) (F) (F) F.C (OC1=NC2=C (C (N (C) [C@@H]3[C@@H] (F) C3) =N1) C=NC (=C2F) C=4C5=C (C=C (O) C4) C=CC (F) =C5C#C) C67N (CC (=C) C6) CCC7
Molecular Formula
C34H29F6N5O4
Molecular Weight
685.62
Storage Conditions
-20°C
Notes
For research use only.
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