NLRP3-IN-34

NLRP3-IN-34 (T10) is a potent small molecule inhibitor of the NLRP3 inflammasome, suppressing ROS generation, IL-1β production (IC50 = 0.48 μM in J774A.1 cells), and pyroptosis. It has demonstrated anti-inflammatory efficacy in vivo, validated in a DSS-induced peritonitis model using C57BL/6 mice, supporting its use in researching inflammatory and autoimmune diseases.