YLL545
YLL545 is a potent and selective VEGFR2 inhibitor that blocks VEGF-induced receptor phosphorylation and downstream signaling (pSTAT3, pERK1/2) in HUVECs. It effectively suppresses endothelial cell proliferation, migration, and tube formation in vitro and demonstrates anti-tumor efficacy by inhibiting angiogenesis and inducing apoptosis in breast cancer mouse models.
Product Specifications
CAS Number
1423126-69-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (NC1=CC=C (OC2=NC=NC=3NN=CC23) C=C1) NC4=CC=CC (=C4) C (F) (F) F
Molecular Formula
C19H13F3N6O2
Molecular Weight
414.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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