PAWI-2
PAWI-2 is a multi-targeting small molecule that activates p53 and inhibits Wnt/β-catenin and TBK1 phosphorylation, inducing apoptosis and cell cycle arrest. It reverses stemness and drug resistance in KRAS-dependent pancreatic cancer stem cells, demonstrating efficacy in both in vitro assays and in vivo orthotopic xenograft models.
Product Specifications
CAS Number
1448427-02-8
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C1N (C2=CC=C (C=C2) S (=O) (=O) N3C=4C=CC=CC4N (C) CC3) CCC1
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC743280-500 1x 500 µL
Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) (TYRP1/3280), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details