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PAWI-2

PAWI-2 is a multi-targeting small molecule that activates p53 and inhibits Wnt/β-catenin and TBK1 phosphorylation, inducing apoptosis and cell cycle arrest. It reverses stemness and drug resistance in KRAS-dependent pancreatic cancer stem cells, demonstrating efficacy in both in vitro assays and in vivo orthotopic xenograft models.

Product Specifications

CAS Number

1448427-02-8

Field of Research

Cell Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Smiles

O=C1N (C2=CC=C (C=C2) S (=O) (=O) N3C=4C=CC=CC4N (C) CC3) CCC1

Molecular Formula

C19H21N3O3S

Molecular Weight

371.45

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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