BMS-986408

BMS-986408 is an orally active dual DGK α/ζ inhibitor that restores T cell-mediated anti-tumor immunity by enhancing T cell signaling[1].

Product Specifications

CAS Number

[2618418-12-3]

UNSPSC

12352005

Target

DGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bms-986408.html

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC[C@H]1CN([C@@H](CN1C2=NC(N(C3=CC=C(N=C32)C#N)C)=O)CC)[C@H](C4=CC=C(C=C4)C(F)(F)F)CC

Molecular Formula

C27H31F3N6O

Molecular Weight

512.57

References & Citations

[1]Wichroski M, et al. Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell Immunotherapies. Cancer Immunol Res. 2025 Jun 12.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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