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CSF1R-IN-22

CSF1R-IN-22 is a potent and selective CSF-1R inhibitor that reprograms M2 macrophages to an M1 phenotype, enhancing CXCL9 secretion and CD8+ T cell infiltration in the tumor microenvironment. It demonstrates synergistic anti-tumor activity with anti-PD-1 therapy in preclinical models, reducing immunosuppressive cell populations like Tregs and MDSCs.

Product Specifications

CAS Number

2760585-35-9

Field of Research

Cell Biology, Signal Transduction

Smiles

C (=C\1/C=2C (=CC (NC (NC=3C=C (C (C) (C) C) ON3) =O) =CC2) NC1=O) \C4=CN=CN4

Molecular Formula

C20H20N6O3

Molecular Weight

392.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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