CSF1R-IN-22
CSF1R-IN-22 is a potent and selective CSF-1R inhibitor that reprograms M2 macrophages to an M1 phenotype, enhancing CXCL9 secretion and CD8+ T cell infiltration in the tumor microenvironment. It demonstrates synergistic anti-tumor activity with anti-PD-1 therapy in preclinical models, reducing immunosuppressive cell populations like Tregs and MDSCs.
Product Specifications
CAS Number
2760585-35-9
Field of Research
Cell Biology, Signal Transduction
Smiles
C (=C\1/C=2C (=CC (NC (NC=3C=C (C (C) (C) C) ON3) =O) =CC2) NC1=O) \C4=CN=CN4
Molecular Formula
C20H20N6O3
Molecular Weight
392.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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