EGFR/HER2-IN-11

EGFR/HER2-IN-11 (compound 20) is an orally bioavailable dual inhibitor of EGFR (IC50=22 nM) and HER2 (IC50=7.7 nM) . It potently inhibits BT-474 cell proliferation (GI50=601 nM) and is a valuable tool for in vitro and in vivo cancer research targeting HER2/EGFR-driven tumors.