EGFR/HER2-IN-11
EGFR/HER2-IN-11 (compound 20) is an orally bioavailable dual inhibitor of EGFR (IC50=22 nM) and HER2 (IC50=7.7 nM) . It potently inhibits BT-474 cell proliferation (GI50=601 nM) and is a valuable tool for in vitro and in vivo cancer research targeting HER2/EGFR-driven tumors.
Product Specifications
CAS Number
1346176-20-2
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C1=C2C (C=CN2CCNCCO) =NC=N1) C3=CC (Cl) =C (OC4=CC (C (F) (F) F) =CC=C4) C=C3
Molecular Formula
C23H21ClF3N5O2
Molecular Weight
491.89
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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