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GLPG3312

GLPG3312 is an orally active, potent pan-SIK inhibitor with low nanomolar IC50 values against SIK1, SIK2, and SIK3. It demonstrates anti-inflammatory and immunomodulatory effects in human primary myeloid cells and mouse models, supporting its use in researching inflammatory and autoimmune diseases.

Product Specifications

CAS Number

2340388-72-7

Product Name Alternative

GLPG 3312

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.53% (May vary between batches)

Solubility

DMSO:80 mg/mL (176.43 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.28 mM)

Smiles

O=C (NC1CC1) C2=C (OC) C=C (C=C2OC (F) F) N3C=NC=4C=C (C=CC43) C=5C=NN (C5) C

Molecular Formula

C23H21F2N5O3

Molecular Weight

453.44

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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