GLPG3312
GLPG3312 is an orally active, potent pan-SIK inhibitor with low nanomolar IC50 values against SIK1, SIK2, and SIK3. It demonstrates anti-inflammatory and immunomodulatory effects in human primary myeloid cells and mouse models, supporting its use in researching inflammatory and autoimmune diseases.
Product Specifications
CAS Number
2340388-72-7
Product Name Alternative
GLPG 3312
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.53% (May vary between batches)
Solubility
DMSO:80 mg/mL (176.43 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.28 mM)
Smiles
O=C (NC1CC1) C2=C (OC) C=C (C=C2OC (F) F) N3C=NC=4C=C (C=CC43) C=5C=NN (C5) C
Molecular Formula
C23H21F2N5O3
Molecular Weight
453.44
Storage Conditions
-20°C
Notes
For research use only.
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