Anticancer agent 258

Anticanceragent 258 is a potent imidazotriazole-based modulator of Nurr1 (EC50=63 nM in N2A cells) and Nur77 (IC50=0.1 pM in HEK293 cells) . This small molecule is a valuable research tool for investigating nuclear receptor function in cancer biology, metabolic disease, and neurological disorder models, both in vitro and in vivo.