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WRN inhibitor 11

WRN inhibitor 11 (Example 17) is a potent, orally bioavailable small molecule targeting the WRN helicase, exhibiting an IC50 of 63 nM. This inhibitor is a valuable research tool for studying DNA repair mechanisms in microsatellite unstable (MSI) cancer models, both in cellular and animal studies.

Product Specifications

CAS Number

3058317-61-3

Field of Research

Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Smiles

O=C (C1=NC=NC (=C1O) C) N2CC3N (C=4C (=O) N5N=C (N=C5N (C4CC) CC (=O) NC6=CC (Cl) =C (C=C6C) C (F) (F) F) C7=CCOCC7) C (C2) CC3

Molecular Formula

C34H35ClF3N9O5

Molecular Weight

742.15

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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