TH9619
TH9619 is a potent dual inhibitor of MTHFD1 and MTHFD2, disrupting folate metabolism to induce folate trapping and cell cycle arrest. Its selective cytotoxicity against MTHFD2-expressing cancer cells supports its application in oncology research, including in vitro mechanistic studies and in vivo xenograft models.
Product Specifications
CAS Number
2379556-22-4
Product Name Alternative
TH-9619, TH 9619
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Purity
98.07% (May vary between batches)
Solubility
DMSO:80 mg/mL (177.24 mM)
Smiles
N (C (CC1=C (N) NC (N) =NC1=O) =O) C=2C=C (F) C (C (N[C@@H] (CCC (O) =O) C (O) =O) =O) =NC2
Molecular Formula
C17H18FN7O7
Molecular Weight
451.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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