TOP1288
TOP1288 is a narrow-spectrum kinase inhibitor targeting P38α, Src, and Syk with IC50 values of 116 nM, 24 nM, and 659 nM, respectively. It effectively blocks inflammatory cytokine release in ex vivo biopsy and in vitro myofibroblast models, supporting its research use in studying inflammatory and fibrotic pathways.
Product Specifications
CAS Number
1630202-02-6
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O (C=1C2=C (C (NC (NC3=C (OC) C (NS (C) (=O) =O) =CC (C (C) (C) C) =C3) =O) =CC1) C=CC=C2) C4=NC (NC5=CC (C (NCCOCCOCCOC) =O) =CC (C#C) =C5) =NC=C4
Molecular Formula
C43H49N7O9S
Molecular Weight
839.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
L1670-16A 50 µg
Leptin, Antagonist, Triple Mutant, Recombinant, Rat (Ob, Obese Protein, Obesity Factor)
Sign In for Pricing
View Details 
E3451-35DX-AP 100 µL
ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian, HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3) (BSA & Azide Free) (AP) discontinued
Sign In for Pricing
View Details MBS6397326-01 0.1 mL
TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) APC
Sign In for Pricing
View Details MBS6397326-02 5x 0.1 mL
TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) APC
Sign In for Pricing
View Details bs-1704R-BF680 100 µL
PAI1 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Sign In for Pricing
View Details