TOP1288
TOP1288 is a narrow-spectrum kinase inhibitor targeting P38α, Src, and Syk with IC50 values of 116 nM, 24 nM, and 659 nM, respectively. It effectively blocks inflammatory cytokine release in ex vivo biopsy and in vitro myofibroblast models, supporting its research use in studying inflammatory and fibrotic pathways.
Product Specifications
CAS Number
1630202-02-6
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O (C=1C2=C (C (NC (NC3=C (OC) C (NS (C) (=O) =O) =CC (C (C) (C) C) =C3) =O) =CC1) C=CC=C2) C4=NC (NC5=CC (C (NCCOCCOCCOC) =O) =CC (C#C) =C5) =NC=C4
Molecular Formula
C43H49N7O9S
Molecular Weight
839.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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