VHL Ligand 14
VHL Ligand 14 (Compound 11) is a von Hippel-Lindau (VHL) binder designed for constructing PROTAC molecules that target the estrogen receptor α (ERα) for degradation, demonstrating an IC50 of 196 nM. This ligand enables the development of bifunctional degraders for probing ERα function in cancer research, applicable in both cellular and in vivo models.
Product Specifications
CAS Number
2010986-87-3
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C ([C@@H] (NC (C) =O) C (C) (C) C) (=O) N1[C@H] (C (N[C@@H] (C) C2=CC=C (C=C2) C3=C (C) N=CS3) =O) C[C@@H] (O) C1
Molecular Formula
C25H34N4O4S
Molecular Weight
486.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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