XL44
XL44 is a small molecule that binds hRpn13, inducing hRpn13-dependent apoptosis and reducing cell viability through a PCLAF-mediated mechanism. It promotes ubiquitin-dependent degradation of the hRpn13 Pru domain and ubiquitin-independent degradation of specific KEN box proteins. This compound is a valuable research tool for studying proteasome regulation, cell death pathways, and targeted protein degradation in both cellular and biochemical assays.
Product Specifications
CAS Number
2637949-91-6
Field of Research
Cell Biology
Smiles
C (=C1C=2C (NC1=O) =CC=C (F) C2) C3=CC (NC (=O) C4=CC=C (OC) C=C4) =CC=C3
Molecular Formula
C23H17FN2O3
Molecular Weight
388.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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