DMBA-SIL-Mal-MMAE

DMBA-SIL-Mal-MMAE is a cytotoxin-linker conjugate for constructing antibody-drug conjugates (ADCs) . It delivers the potent tubulin inhibitor monomethyl auristatin E (MMAE) to target cells and has demonstrated antitumor efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.

Product Specifications

CAS Number

2923885-49-6

Smiles

[C@H] ([C@H] (C (N[C@@H] ([C@@H] (O) C1=CC=CC=C1) C) =O) C) (OC) [C@]2 (N (C (C[C@H] ([C@@H] (N (C ([C@@H] (NC ([C@@H] (N (C (OC (C (NCCOCCOCCOCCOCCN3C (=O) C=CC3=O) =O) C4=CC=C (NC (OCC5=CC (OC) =CC (OC) =C5) =O) C=C4) =O) C) C (C) C) =O) C (C) C) =O) C) [C@H] (CC) C) OC) =O) CCC2) [H]