PROTAC FLT-3 degrader 4
PROTACFLT-3 degrader 4 is an orally bioavailable, CRBN-recruiting PROTAC that selectively degrades FLT3-ITD mutant proteins via the ubiquitin-proteasome system. It demonstrates potent anti-leukemic activity in cellular models and is a valuable tool for investigating targeted protein degradation in FLT3-ITD mutant AML research, both in vitro and in vivo.
Product Specifications
CAS Number
2956722-48-6
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1N (C (=O) C=2C1=CC (=CC2) N3CCC (CN4CCN (CC (NC=5C (C) =C (/C=C\6/C=7C (NC6=O) =CC=C (F) C7) NC5) =O) CC4) CC3) C8C (=O) NC (=O) CC8
Molecular Formula
C39H41FN8O6
Molecular Weight
736.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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