HA-9104
HA-9104 is a selective cullin-5 neddylation inhibitor that binds the V30 pocket of UBE2F, reducing its protein levels. This disruption of the UBE2F-CRL5 axis induces DNA damage, apoptosis, and cell cycle arrest, demonstrating potent anti-proliferative and radiosensitizing effects in lung and pancreatic cancer models in vitro.
Product Specifications
CAS Number
2412367-83-8
Smiles
O=C (C=CC1=CNC=2N=CC=CC12) NC3=CC=C (C=C3) N4CCN (C (=O) C5=CC=C (C=C5) C) CC4
Molecular Formula
C28H27N5O2
Molecular Weight
465.55
Storage Conditions
-20°C
Notes
For research use only.
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