PROTAC EGFR degrader 11
PROTAC EGFR degrader 11 (Compound B71) is a potent CRBN-based degrader with a DC50 <100 nM for EGFR, also degrading FAK and RSK1. It inhibits proliferation of BaF3 cells (IC50 <100 nM), supporting its use in targeted protein degradation research for oncology, both in vitro and in vivo.
Product Specifications
CAS Number
3034244-71-5
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1NC (=O) C (C2=CC=C (C=C2F) N3CCC (OCCN4CCN (CC4) C5CCN (C6=CC (OC) =C (C=C6CC) NC7=NC=C (Cl) C (=N7) NC8=CC=C (OC) C=C8N (C) S (=O) (=O) C) CC5) CC3) CC1
Molecular Formula
C49H64ClFN10O7S
Molecular Weight
991.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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