TLR8 agonist 9
TLR8 agonist9 (Compound II-77) is a potent and plasma-stable TLR8 agonist (EC50 0.25-1 μM) that induces TNFα secretion. It demonstrates significant antitumor efficacy in vivo, achieving 97% tumor growth inhibition in an MC38-HER2 mouse model, supporting its use in immuno-oncology and inflammation research.
Product Specifications
CAS Number
3034750-61-0
Field of Research
Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery
Smiles
O=C1C=CC (=O) N1CC2OCC (C (=O) N3CC4=CC (=CN=C4CC3) NC (=O) C5 (C=6C=CC=7C=C (C (=O) N (CCO) CCC) CC (=NC7C6) N) CC5) CO2
Molecular Formula
C38H43N7O8
Molecular Weight
725.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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