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SQA1

SQA1 is a phthalamide-derived small molecule that functions as a dual CCR6 antagonist (Kd 250 nM) and CXCR2 inhibitor. It stabilizes the closed conformation of an intracellular allosteric pocket overlapping the G-protein binding site, making it a valuable tool for investigating chemokine receptor signaling in inflammatory and autoimmune disease models.

Product Specifications

CAS Number

1255915-27-5

Field of Research

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Smiles

N (C1=C (N[C@H] (CC) C2=CC (C (C) C) =CO2) C (=O) C1=O) C=3C (O) =C (C (N (C) C) =O) N=CC3

Molecular Formula

C22H26N4O5

Molecular Weight

426.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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