SQA1
SQA1 is a phthalamide-derived small molecule that functions as a dual CCR6 antagonist (Kd 250 nM) and CXCR2 inhibitor. It stabilizes the closed conformation of an intracellular allosteric pocket overlapping the G-protein binding site, making it a valuable tool for investigating chemokine receptor signaling in inflammatory and autoimmune disease models.
Product Specifications
CAS Number
1255915-27-5
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Smiles
N (C1=C (N[C@H] (CC) C2=CC (C (C) C) =CO2) C (=O) C1=O) C=3C (O) =C (C (N (C) C) =O) N=CC3
Molecular Formula
C22H26N4O5
Molecular Weight
426.47
Storage Conditions
-20°C
Notes
For research use only.
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