K-Opioid receptor agonist-1
Compound 5a is a potent and brain-penetrant κ-opioid receptor agonist (Ki = 0.25 nM, EC50 = 2 nM) with a brain/plasma ratio of 0.50-0.65. It demonstrates anti-inflammatory activity in preclinical models of arachidonic acid- and oxazolidinone-induced dermatitis, supporting research in neuropharmacology and inflammatory skin disease.
Product Specifications
CAS Number
1816990-29-0
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Smiles
C (CC1=CC (Cl) =C (Cl) C=C1) (=O) N2[C@]3 ([C@@] (N (C (OC) =O) CC2) (CCC[C@@H]3N4CCCC4) [H]) [H]
Molecular Formula
C22H29Cl2N3O3
Molecular Weight
454.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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