WRN inhibitor 8
WRN inhibitor 8 (Example 224) is a potent small molecule inhibitor of the WRN helicase with an IC50 of 48 nM. It is a valuable chemical tool for cancer research, particularly in studying synthetic lethal approaches for microsatellite unstable (MSI) cancers in both in vitro and in vivo models.
Product Specifications
CAS Number
3026502-95-1
Field of Research
Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology
Smiles
O (C=1C (C (N[C@H] (/C=C/S (C) (=O) =O) C2CC2) =O) =CN=C (C (F) (F) C3CC3) N1) C4=CC=CC=C4
Molecular Formula
C22H23F2N3O4S
Molecular Weight
463.50
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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