TK-642
TK-642 is a potent, orally active SHP2 inhibitor (IC50 = 2.7 nM) derived from pyrazole and pyrazine scaffolds. It suppresses esophageal carcinoma cell proliferation and induces apoptosis in vitro, serving as a valuable chemical probe for studying SHP2-dependent cancer signaling pathways.
Product Specifications
CAS Number
2765183-10-4
Field of Research
Metabolism Research
Smiles
ClC=1C=NC=CC1SC2=NNC=3N=C (C=NC23) N4CCC (C) (CN) CC4
Molecular Formula
C17H20ClN7S
Molecular Weight
389.91
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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