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TK-642

TK-642 is a potent, orally active SHP2 inhibitor (IC50 = 2.7 nM) derived from pyrazole and pyrazine scaffolds. It suppresses esophageal carcinoma cell proliferation and induces apoptosis in vitro, serving as a valuable chemical probe for studying SHP2-dependent cancer signaling pathways.

Product Specifications

CAS Number

2765183-10-4

Field of Research

Metabolism Research

Smiles

ClC=1C=NC=CC1SC2=NNC=3N=C (C=NC23) N4CCC (C) (CN) CC4

Molecular Formula

C17H20ClN7S

Molecular Weight

389.91

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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