PROTAC EGFR degrader 10
PROTAC EGFR degrader 10 (Compound B56) is a cereblon-directed bifunctional molecule that potently degrades EGFR, FAK, and RSK1 with a DC50 below 100 nM. It demonstrates potent anti-proliferative activity in cellular models, including BaF3 cells harboring EGFR mutations, supporting its use in targeted protein degradation research for oncology.
Product Specifications
CAS Number
3034244-56-6
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1NC (=O) C (C2=CC=C (C=C2) N3CCC (OCCN4CCN (CC4) C5CCN (C6=CC (OC) =C (C=C6CC) NC7=NC=C (Cl) C (=N7) NC8=CC=C (OC) C=C8N (C) S (=O) (=O) C) CC5) CC3) CC1
Molecular Formula
C49H65ClN10O7S
Molecular Weight
973.62
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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