PROTAC EGFR degrader 10

PROTAC EGFR degrader 10 (Compound B56) is a cereblon-directed bifunctional molecule that potently degrades EGFR, FAK, and RSK1 with a DC50 below 100 nM. It demonstrates potent anti-proliferative activity in cellular models, including BaF3 cells harboring EGFR mutations, supporting its use in targeted protein degradation research for oncology.