TEAD-IN-12

TEAD-IN-12 (58B) is a potent, orally bioavailable small molecule inhibitor of the TEAD transcription factors, with sub-100 nM IC50 activity and a 3.6-hour half-life in mice. It is a valuable chemical probe for investigating the Hippo signaling pathway in cancer research, enabling both in vitro mechanistic studies and in vivo efficacy models.