Amlodipine (maleate)

Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer[1][2][3].

Product Specifications

CAS Number

[88150-47-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Amlodipine-maleate.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 120 mg/mL (ultrasonic)

Smiles

O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.OC(/C=C\C(O)=O)=O

Molecular Formula

C24H29ClN2O9

Molecular Weight

524.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492 (2-3) :103-12.|[2]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41 (2) :80-87.|[3]Kishen G. Bulsara, et al. Amlodipine.|[4]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50 (5) :896]. Drugs. 1995;50 (3) :560-586.