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YM-344031

YM-344031 is a potent and orally bioavailable CCR3 antagonist, inhibiting eotaxin-1 and RANTES binding with IC50 values of 3.0 and 16.3 nM, respectively. It blocks CCR3-mediated calcium flux, chemotaxis, and eosinophil shape change in vitro, and has demonstrated efficacy in preventing allergic skin reactions in murine models.

Product Specifications

CAS Number

671204-98-1

Field of Research

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Smiles

C (C1=CC2=C (C=C1) C=C (F) C=C2) N3C[C@H] (NC (C=C4CCN (C (=O) C5=C (C) C=CC=N5=O) CC4) =O) CC3

Molecular Formula

C29H31FN4O3

Molecular Weight

502.58

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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