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PARP1-IN-20

PARP1-IN-20 (19A10) is a potent PARP1 inhibitor with an IC50 of 4.62 nM, yet it displays a significantly weaker PARP-trapping activity compared to Veliparib (IC50 >100 μM in MDA-MB-436 cells) . This profile makes it a useful chemical tool for studying catalytic inhibition in cancer research, applicable in both in vitro and in vivo models of BRCA-deficient cancers.

Product Specifications

CAS Number

2659357-95-4

Field of Research

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Smiles

O=C (N) C=1C=CC=C2N=C (NC21) C=3C=CC (=CC3) C (=O) N4CCN (C (=O) C=5N=C (Br) SC5) CC4

Molecular Formula

C23H19BrN6O3S

Molecular Weight

539.40

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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