KT-333
KT-333 is a heterobifunctional PROTAC degrader that selectively targets STAT3 for ubiquitination and degradation via recruitment of the VHL E3 ligase. It is a research tool for investigating STAT3-dependent oncology, with utility demonstrated in both cellular assays and in vivo tumor models for hematologic and solid cancers.
Product Specifications
CAS Number
2502186-79-8
Product Name Alternative
KT333
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.12% (May vary between batches)
Solubility
DMSO:100 mg/mL (79.51 mM)
Smiles
C (N[C@H] (COC1=C (Cl) C (CCCC (N[C@H] (C (=O) N2[C@H] (C (N[C@@H] (C) C3=CC=C (C=C3) C4=C (C) N=CS4) =O) C[C@@H] (O) C2) C (C) (C) C) =O) =CC=C1) CCC (N) =O) (=O) [C@H]5N6[C@] (CC5) (CCN (C (C) =O) C[C@H] (NC (=O) C7=CC=8C (N7) =CC=C (C (P (=O) (O) O) =O) C8) C6=O) [H]
Molecular Formula
C60H74ClN10O14PS
Molecular Weight
1257.78
Storage Conditions
-20°C
Notes
For research use only.
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