UNC8153
UNC8153 is a potent and selective NSD2 degrader (Kd = 24 nM) that effectively depletes NSD2 protein and reduces global H3K36me2 levels via proteasomal degradation. This tool compound enables the investigation of NSD2 biology in cancer research and epigenetics, supporting both in vitro and in vivo experimental applications.
Product Specifications
CAS Number
2929304-60-7
Field of Research
Epigenetics & Chromatin
Smiles
O=C (NC1=CC=C (C=C1) C (=O) NCCCCCCN) C2=CC=C (C=C2) CN (C (=O) C3=CC=C4NC (=O) COC4=C3) C5CC5
Molecular Formula
C33H37N5O5
Molecular Weight
583.68
Storage Conditions
-20°C
Notes
For research use only.
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