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G-1749

G-1749 is a research compound that modulates IRE1 activity. It stimulates the RNase function of unphosphorylated IRE1 and the IRE1-KR-0P mutant while inhibiting the phosphorylated form (IRE1-3P), without affecting the IRE1 monomer-dimer equilibrium. This makes it a valuable tool for studying the unfolded protein response (UPR) in both cellular and biochemical assays.

Product Specifications

CAS Number

2245057-57-0

Product Name Alternative

G 1749, G1749

Purity

96.22% (May vary between batches)

Smiles

CCOC (=O) Nc1cccc2c (Oc3ncccc3-c3ccnc (N[C@H]4CCCNC4) n3) c (C) ccc12

Molecular Formula

C28H30N6O3

Molecular Weight

498.59

Storage Conditions

-20°C

Notes

For research use only.

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