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HG-7-85-01-NH2

SNIPER (ABL) -033 is a heterobifunctional degrader that links the ABL inhibitor HG-7-85-01 to an IAP ligand, inducing targeted degradation of BCR-ABL with a DC50 of 0.3 μM. It serves as a research tool for studying targeted protein degradation in oncology, applicable in both cellular and in vivo models of BCR-ABL-driven cancers.

Product Specifications

CAS Number

1258391-29-5

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Smiles

C (C1=C (C (F) (F) F) C=C (NC (=O) C2=CC (=CC=C2) C=3N=C4C (=CC3) N=C (N) S4) C=C1) N5CCN (CC) CC5

Molecular Formula

C27H27F3N6OS

Molecular Weight

540.6

Storage Conditions

-20°C

Notes

For research use only.

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