HA-14-1
HA-14-1 is a Bcl-2 surface pocket inhibitor (IC50 ~9 μM) that disrupts Bcl-2/Bak interactions, leading to Apaf-1-mediated caspase activation and apoptosis. It has demonstrated potent pro-apoptotic activity in vitro, such as in HL-60 acute myeloid leukemia cells. This small molecule is a useful research tool for studying mitochondrial apoptosis pathways in cancer models.
Product Specifications
CAS Number
927635-64-1
Field of Research
Cell Biology
Smiles
C (C (OCC) =O) (C#N) C1C=2C (OC (N) =C1C (OCC) =O) =CC=C (Br) C2
Molecular Formula
C17H17BrN2O5
Molecular Weight
409.2
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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