1-Aminodecylidene bis-Phosphonic Acid

1-Aminodecylidenebis-phosphonic acid is a potent and selective acid sphingomyelinase inhibitor (IC50= 20 nM), showing >5000-fold selectivity over neutral sphingomyelinase. It effectively blocks dexamethasone-induced apoptosis in HepG2 cells in vitro, making it a valuable research tool for studying ceramide-mediated pathways in apoptosis and liver disease models.