F-Amidine TFA
F-amidine is a selective, irreversible inhibitor of protein arginine deiminases (PADs), particularly PAD1 and PAD4. It covalently modifies an active site cysteine, inactivating the enzymes. This compound also exhibits cytotoxic activity against several cancer cell lines, supporting its use in researching PAD-related pathways in cancer and autoimmune diseases.
Product Specifications
CAS Number
877617-46-4
Field of Research
Epigenetics & Chromatin, Immunology & Inflammation
Smiles
C (C (O) =O) (F) (F) F.C (N[C@@H] (CCCNC (CF) =N) C (N) =O) (=O) C1=CC=CC=C1
Molecular Formula
C14H19FN4O2?CF3COOH
Molecular Weight
408.4
Storage Conditions
-20°C
Notes
For research use only.
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