(-) -Neplanocin A

(−) -Neplanocin A is a potent, irreversible inhibitor of SAH hydrolase (Ki=8.39 nM), leading to SAH accumulation and inhibition of SAM-dependent methyltransferases. It demonstrates significant antitumor activity against L1210 leukemia cells and broad-spectrum antiviral efficacy, notably against vesicular stomatitis virus, surpassing the potency of reversible analogs like 3-deazaneplanocin.