PBD dimer-2
PBD dimer-2 (2c) is a C8-linked pyrrolobenzodiazepine dimer capable of cross-linking the 5′-Pu-GA (T/A) TC-Py DNA sequence, spanning an extra base pair. It is investigated as a cytotoxic payload for antibody-drug conjugates (ADCs) in oncology research, with studies demonstrating its activity in both in vitro and in vivo models.
Product Specifications
CAS Number
145325-57-1
Smiles
O=C1C=2C (=CC (OCCCCCOC3=C (OC) C=C4C (=C3) N=C[C@]5 (N (C4=O) CCC5) [H]) =C (OC) C2) N=C[C@]6 (N1CCC6) [H]
Molecular Formula
C31H36N4O6
Molecular Weight
560.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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