PT-65
PT-65 is a potent and selective degrader of GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells. This molecule is a valuable chemical tool for investigating GSK3's role in Alzheimer's disease pathology and related neurodegenerative research in cellular models.
Product Specifications
CAS Number
2721998-87-2
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCCOCCOCCOCCOCCOCCN4C=C (CCCCN5CCN (S (=O) (=O) C6=CC=C (C=C6) C7=NC (C (NC=8C=CC=NC8) =O) =C (N) N=C7) CC5) N=N4
Molecular Formula
C51H63N13O12S
Molecular Weight
1082.19
Storage Conditions
-20°C
Notes
For research use only.
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