ZDLD20
Product Specifications
UNSPSC Description
ZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 6.51 μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity[1].
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zdld20.html
Purity
99.84
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)NC4=NC=C(N5CCN(C)CC5)C=C4
Molecular Weight
386.45
References & Citations
[1]Deping Li, et al. Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer. Bioorg Chem. 2022 Apr;121:105659.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115909/ZDLD20-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115909/ZDLD20-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2762279-02-5
Available Sizes
Curated Selection
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