(±) -N-desmethyl Venlafaxine hydrochloride

(±) -N-desmethyl Venlafaxine is an active SNRI metabolite of venlafaxine, formed via CYP3A4. In vitro, it inhibits norepinephrine and serotonin reuptake (IC50 = 4.7 and 1.6 μM in rat synaptosomes), and in vivo, it reverses reserpine-induced hypothermia in mice (MED = 10 mg/kg) .