Indium (III) thiosemicarbazone 5b

Indium (III) thiosemicarbazone 5b is a cytotoxic agent effective against multiple cancer cell lines, including cisplatin-resistant MCF-7/DDP cells, by inhibiting PI3K/Akt/mTOR signaling and reducing P-gp. In vivo, it suppresses tumor growth in xenograft models, and liposomal formulations enhance its pro-apoptotic and autophagic activity, supporting its study in oncology and drug resistance research.