N-desmethyl Regorafenib N-oxide
N-Desmethyl Regorafenib N-oxide is a pharmacologically active metabolite of regorafenib, formed via CYP3A4 metabolism. It potently inhibits kinases including VEGFR2 and B-RAF in vitro and demonstrates in vivo antitumor efficacy in xenograft models, such as HT-29 and MDA-MB-231, at low doses.
Product Specifications
CAS Number
835621-12-0
Field of Research
Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C=1C=C (C (N) =O) N (=O) =CC1) C2=CC (F) =C (NC (NC3=CC (C (F) (F) F) =C (Cl) C=C3) =O) C=C2
Molecular Formula
C20H13ClF4N4O4
Molecular Weight
484.79
Storage Conditions
-20°C
Notes
For research use only.
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