GSK3368715 hydrochloride

GSK3368715 is a potent, orally bioavailable, and SAM-noncompetitive Type I PRMT inhibitor with low nM IC50 values. It demonstrates broad anti-tumor activity in preclinical models, alters RNA splicing, and shows synergistic tumor growth inhibition when combined with the Type II PRMT inhibitor GSK3326595. This molecule is a valuable tool for investigating PRMT biology in cancer research, both in vitro and in vivo.