ACP-105

ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.

Product Specifications

CAS Number

[899821-23-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ACP-105.html

Purity

98.99

Solubility

DMSO : ≥ 103 mg/mL

Smiles

N#CC1=CC=C(N2[C@@H]3C[C@](O)(C)C[C@H]2CC3)C(C)=C1Cl

Molecular Formula

C16H19ClN2O

Molecular Weight

290.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Schlienger N, et al. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. J Med Chem. 2009 Nov 26;52 (22) :7186-91.|[2]Dayger C, et al. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. Brain Res. 2011 Mar 24;1381:134-40.